Iontophoretically administering a cosmetic agent requires an active electrode and a return electrode secured to the skin (150). The active electrode includes a flexible biocompatible substrate (20, 170) having a therapeutic face (106, 206) configured for disposition toward the skin (150) and an exterior periphery (32, 182) shaped to facilitate conformance of the substrate (20, 170) to the skin (150) over an intended treatment region. A flexible electrically conductive layer (110, 210) is disposed on the therapeutic face (106, 206). The side of the conductive layer (110, 210) opposite from the substrate (20, 170) defines a driving face (120, 220) to which is affixed an electrically conductive adhesive matrix (82, 192) comprised of a material capable of repeatedly releasably securing the active electrode to the skin (150) through an applied solution (156, 158) of the cosmetic agent. A power source (76, 186) electrically connectable to the return electrode and to the conductive layer (110, 210) of the active electrode causes migration of the cosmetic agent away from the adhesive matrix (82, 192) into the skin (150).
