CHIMERES VIRALES COMPRENANT DES ELEMENTS GENETIQUES DE CAEV ET DE VIH-1

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专利权人:

UNIVERSITY OF SOUTHERN CALIFORNIA

发明人:

DOUVAS, ANGELINE,PARR, TYLER B.

申请号：

CA2330618

公开号：

CA2330618C

申请日:

1999.04.30

申请国别(地区):

CA

年份:

2012

代理人:

摘要：

The present invention provides a polynucleotide comprising portions of thegenomes of caprine arthritis-encephalitis virus and HIV-1, resulting in achimeric retrovirus referred to as a "CHIV". The invention also provides avaccine comprising a CHIV immunogen and a pharmaceutically acceptable carrier.A method of stimulating an immune response in an individual against humanimmunodeficiency virus-1 infection by administering a therapeuticallyeffective amount of a CHIV immunogen is also provided. The invention furtherprovides a method of stimulating an immune response in vitro by contacting alymphocyte with a therapeutically effective amount of a CHIV immunogen.

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