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КОНЪЮГАТ МЕНИНГОКОККА СЕРОГРУППЫ Х
专利权人:
НОВАРТИС АГ (CH)
发明人:
РОМАНО Мария Розария (IT),МИКОЛИ Франческа (IT),БЕРТИ Франческо (IT),АДАМО Роберто (IT),КОСТАНТИНО Паоло (IT)
申请号:
RU2014151567
公开号:
RU2014151567A
申请日:
2013.05.22
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. The conjugate of the capsular polysaccharide of Neisseria meningitidis serogroup X and nositelya.2 molecule. The conjugate of claim 1, wherein the conjugate is prepared by a method comprising the steps of: (a) oxidation of the primary hydroxyl group in the capsular polysaccharide to obtain a polysaccharide oxidized to the aldehyde group. and (b) coupling the oxidized polysaccharide to a carrier molecule via the aldehyde group to obtain thereby konyugata.3. The conjugate of claim. 2, wherein oxidation in step (a) is an oxidation of the primary hydroxyl group at 1-10% of the residues in the capsular polisaharide.4. The conjugate of claim. 2, where the binding in step (b) is pryamym.5. The conjugate of claim 1, wherein the conjugate is prepared by a method comprising the steps of: (a) reductive amination of the reducing end of the capsular polysaccharide to obtain a polysaccharide modified with primary amino group bound to the C-1 atom of the terminal subunit covalent bond. and (b) binding the modified polysaccharide to a carrier molecule by a primary amino group, to obtain thereby konyugata.6. The conjugate of claim 1, wherein the conjugate is prepared by a method comprising the steps of: (a) reducing a reducing end of the capsular polysaccharide to obtain a polysaccharide modified with two adjacent hydroxyl groups at this end. (B) oxidative cleavage of the neighboring hydroxyl groups to produce further modified polysaccharide with the aldehyde group at the end (C) reductive amination of an aldehyde group to obtain further modified polysaccharide with the primary amino group at the end and (d) further modified polysaccharide binding molecule1. Конъюгат капсульного полисахарида Neisseria meningitidis серогруппы X и молекулы носителя.2. Конъюгат по п. 1, где конъюгат получают с помощью способа, включающего стадии: (а) окисления первичной гидроксильной группы в капсульном полисахариде с получением окисленного полисахарида с альдегидной группой и (b) связывания окислен
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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