PROBLEM TO BE SOLVED: To provide an acute heart failure therapeutic agent containing a direct sGC activator without depending on heme, as an active ingredient.SOLUTION: An acute heart failure therapeutic agent contains, (-)-4-{[N-(4-carboxybutyl)-N-[(2R)-2-[4-(2-phenylethyl)benzyloxy]-2-phenylethyl]amino]methyl}benzoic acid or a pharmaceutically acceptable salt thereof as an active ingredient, and it is to be intravenously administered, in a persistent manner, at an administration rate of 0.001-10 μg/kg/min, as an educt of the active ingredient.SELECTED DRAWING: Figure 1COPYRIGHT: (C)2018,JPO&INPIT【課題】ヘムに依存しない直接的sGC活性化剤を有効成分とする急性心不全の治療薬の提供。【解決手段】(-)-4-{[N-(4-カルボキシブチル)-N-[(2R)-2-[4-(2-フェニルエチル)ベンジルオキシ]-2-フェニルエチル]アミノ]メチル}安息香酸またはその薬学的に許容される塩を有効成分として含有し、当該有効成分の遊離体として0.001~10μg/kg/分の投与速度で持続静脈内投与するための急性心不全治療薬。【選択図】図1
