The provision of a therapeutic composition and periodontal disease prevention, including as an active ingredient and its mixing herbal material extract [challenge] king oyster mushroom, Notoginseng root and Acanthopanax bark. More particularly, the invention relates to therapeutic compositions and periodontal disease prevention and as an active ingredient and its mixed herbal material extract eryngii, Notoginseng root and Acanthopanax bark, The invention relates to osteogenic In order to reduce the activity and generation of osteoclasts to promote the expression of OPG in the cell, it is possible to suppress the destruction of the alveolar bone by inhibiting the proliferation of osteoclasts, the proliferation of gingival fibroblasts and periodontal ligament cells It is intended as an active ingredient and its mixing herbal material extract to maintain, about the therapeutic composition and periodontal disease prevention. [Selection] Figure Figure 1【課題】エリンギ、五加皮及び三七根の混合生薬材抽出物及びそれを有効成分として含む歯周疾患予防及び治療用組成物の提供。【解決手段】本発明は、エリンギ、五加皮及び三七根の混合生薬材抽出物及びそれを有効成分として含む歯周疾患予防及び治療用組成物に関するもので、より詳細には、造骨細胞でOPGの発現を促進させて破骨細胞の生成及び活性を減少させて、破骨細胞の増殖を抑制して歯槽骨の破壊を抑制して、歯周靭帯細胞及び歯肉繊維芽細胞の増殖を維持する混合生薬材抽出物及びそれを有効成分として含む、歯周疾患予防及び治療用組成物に関するものである。【選択図】図1
