Prosthesis comprises zirconia, supplements the lost portion of the natural bone is discolored color that approximates the natural bone due to heat treatment after the γ-ray sterilization. The color in the L*a*b* color system, L* is 60 to 90, a* is -5 to 10, b* is -5 to 10. The heating process is a 100℃ to 300℃ the maximum temperature. The prosthesis is an implant for osseointegration embedded in natural bone.本發明為含有二氧化鋯,用以填補天然骨頭之缺損部份的補綴物,其藉γ射線殺菌處理後之加熱處理,變色為近似天然骨頭之顏色。近似之顏色在L*a*b*表色系統中,L*為60~90,a*為-5~10,b*為-5~10。加熱處理之最高溫度為100℃~300℃。補綴物為植入天然骨頭中以進行骨整合之植入物。