Daniel Joseph Coady;Yi Yan Yang;Kazuki Fukushima;James Lupton Hedrick
发明人:
Daniel Joseph Coady,Kazuki Fukushima,James Lupton Hedrick,Yi Yan Yang
申请号：
US13077005
公开号：
US08642086B2
申请日:
2011.03.31
申请国别(地区):
US
年份:
2014
代理人:
摘要：
A composition of matter comprises a cationic polymer comprising a polycarbonate chain fragment, the polycarbonate chain fragment comprising a repeat unit comprising a side chain moiety containing a quaternary amine group； and a non-charged polymer comprising a polyester chain segment and a poly(alkylene oxide) chain segment； wherein i) the cationic polymer and the non-charged polymer are amphiphilic and biocompatible, ii) the cationic polymer and the non-charged polymer form a mixed complex by non-covalent interactions in water, and iii) the mixed complex is a more effective antimicrobial agent against at least a Gram-negative microbe compared to the cationic polymer and the non-charged polymer alone when tested using otherwise identical conditions.
