PURPOSE: A lymphatic vascularization composition containing granulocyte-colony stimulating-factors is provided to induce capillarization, cell proliferation, and lymphatic sprout of human lymphatic vascular endothelial cells. CONSTITUTION: A lymphatic vascularization composition contains granulocyte-colony stimulating-factors as an active ingredient. The granulocyte-colony stimulating-factors include granulocyte macrophage colony stimulating factors(GM-CSF) and macrophage colony stimulating factors(MCSF). A composition for preventing or treating lymphedema contains the granulocyte-colony stimulating-factors as an active ingredient. A composition for preventing or treating lymphatic vessel loss or lymphopenia contains the granulocyte-colony stimulating-factors. An agent for enhancing ERK1/2 phosphorylation and Akt phosphorylation contains the granulocyte-colony stimulating-factors as an active ingredient.본 발명은 과립구집락자극인자를 유효성분으로 포함하는 림프관 생성 유도제에 관한 것이다. 본 발명에서는 과립구집락자극인자가 사람 림프관내피 세포에서 세포 유주, 모세관 형성, 세포 증식, 림프관 발아를 유도하는 것을 확인하였고, 이러한 기작을 통하여 림프관을 생성한다. 또한 과립구집락자극인자는 사람 림프관내피 세포에서 맵 키나아제(MAP kinase)와 Akt 신호전달계를 통하여 림프관 생성을 유도할 수 있다.
