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Hydrophilic self-immolative linkers and conjugates thereof
专利权人:
AbGenomics International Inc.;BioAlliance C.V.
发明人:
Rong-Hwa Lin,Shih-Yao Lin,Yu-Chi Hsieh,Chiu-Chen Huang
申请号:
US14654486
公开号:
US09943610B2
申请日:
2013.12.20
申请国别(地区):
US
年份:
2018
代理人:
摘要:
The present disclosure provides compounds with a hydrophilic self-immolative linker, which is cleavable under appropriate conditions and incorporates a hydrophilic group to provide better solubility of the compound. The compounds of the present disclosure comprise a drug moiety, a targeting moiety capable of targeting a selected cell population, and a linker which contains an acyl unit, an optional spacer unit for providing distance between the drug moiety and the targeting moiety, a peptide linker which can be cleavable under appropriate conditions, a hydrophilic self-immolative linker, and an optional second self-immolative spacer or cyclization self-elimination linker.
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