MEMORIAL SLOAN-KETTERING CANCER CENTER;AGENUS INC.;LUDWIG INSTITUTE FOR CANCER RESEARCH LTD.
发明人:
LEGER, OLIVIER,SIEBERT, VOLKER,VAN DIJK, MARC,SCHAER, DAVID,TSUJI, TAKEMASA,RITTER, GERD,GONZALEZ, ANA M.,WILSON, NICOLAS S.,ZAPPASODI, ROBERTA,MERGHOUB, TAHA,WOLCHOK, JEDD DAVID,UNDERWOOD, DENNIS J.
申请号：
CA2949998
公开号：
CA2949998A1
申请日:
2015.05.28
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
The present disclosure provides antibodies that specifically bind to human glucocorticoid-induced TNFR family related receptor (GITR) and compositions comprising such antibodies. In a specific aspect, the antibodies specifically bind to human GITR and modulate GITR activity, e.g., enhance, activate or induce GITR activity, utilizing such antibodies. The present disclosure also provides methods for treating disorders, such as cancer and infectious diseases, by administering an antibody that specifically binds to human GITR and modulates GITR activity e.g., enhances, activates or induces GITR activity.
