Mei Huang;Amato John Giaccia;Denise A. Chan;Joseph C. Wu
发明人:
Joseph C. Wu,Amato John Giaccia,Mei Huang,Denise A. Chan
申请号：
US12998075
公开号：
US20120004283A1
申请日:
2009.09.15
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Short hairpin RNA (shRNA) interference therapy targeting hypoxia inducible factor—lot (HIF-1 α) prolyl-4-hydroxylase protein (HIF-PHD2) is used for treatment of myocardial ischemia. This treatment can be followed noninvasively by molecular imaging. Provided are compositions comprising novel vectors encoding shRNA targeting the HIF-1α and asparaginyl hydroxylase genes. The vectors encoding shRNA are also useful for the treatment of cardiac diseases, peripheral vascular diseases and decubitis ulcers.
