UTILISATION DU TELMISARTAN POUR LA PRÉVENTION ET LE TRAITEMENT DE LA MALADIE DU GREFFON CONTRE L'HÔTE ET D'AUTRES MALADIES AUTO-IMMUNES ET ALLO-IMMUNES

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专利权人:

Hackensack University Medical Center

发明人:

申请号：

EP16808068.7

公开号：

EP3307069A4

申请日:

2016.06.03

申请国别(地区):

EP

年份:

2019

代理人:

摘要：

The described invention relates to methods for preventing or treating graft-versus-host disease while preserving a graft-versus-tumor effect, increasing survival of, preserving alloreactivity, or a combination thereof in a patient with a tumor receiving a transplant. The described methods comprise administering to the patient a therapeutic amount of a pharmaceutical composition comprising a Rho kinase inhibitor compound, e.g., telmisartan or related angiotensin receptor blockers, and a pharmaceutically acceptable excipient. The therapeutic amount may be effective to attenuate graft-versus-host disease and to preserve the graft-versus-tumor effect of the transplant.

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