Alexander Kutikov,Vladimir Kolenko,Seth M. Cohen,Robert G. Uzzo,Ervin Teper
申请号：
US14610044
公开号：
US20150147291A1
申请日:
2015.01.30
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The invention provides zinc chelating agents and formulations thereof that deplete XIAP in cancer cells and sensitize the cells to apoptosis-inducing agents. The invention provides methods for sensitizing apoptosis-resistant cancer cells to apoptosis-inducing agents, as well as methods for treating a subject with a combined therapy of a zinc chelating agent and an apoptosis-inducing agent.
