Woo-Keun Kim,Sangwoo Lee,Seokjoo Yoon,Chul Min Park
申请号：
US16562298
公开号：
US20200078279A1
申请日:
2019.09.05
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention relates to a bis phenyl hexa triene derivative, a preparation method thereof and a composition for skin whitening comprising the same as an active ingredient. The said derivative inhibits the expression of tyrosinase, TRP 1 (tyrosinase-related protein 1), TRP 2 (tyrosinase-related protein 2) or MITF (microphthalmia-associated transcription factor) gene which produces a precursor necessary for the generation of melanin, suppresses the activity of tyrosinase, eventually inhibits the biosynthesis of melanin, is safe due to low cytotoxicity, and has less side effects and excellent antioxidative effect, so that it can be effectively used as a composition for skin whitening.
