Systems, devices, and methods for electroporation ablation therapy are disclosed, with the method including configuring a first sequence of subsets of one or more electrode channels of a signal generator as an anode sequence. Each electrode channel includes an electronic switch configured to switch between an ON state and an OFF state, and a drive circuit coupled to the electronic switch to control the state of the electronic switch. The method also includes configuring a second sequence of subsets of one or more electrode channels of the signal generator as a cathode sequence such that respective electrode channels of the first and second sequences are paired for energy delivery. The method also includes delivering, from an energy source, a pulse waveform to a set of electrodes via the paired sequences of electrode channels.
