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Contrast reagent leakage correction in dynamic susceptibility contrast magnetic resonance imaging
专利权人:
William Rooney;Xin Li
发明人:
William Rooney,Xin Li
申请号:
US14694319
公开号:
US09619875B2
申请日:
2015.04.23
申请国别(地区):
US
年份:
2017
代理人:
摘要:
Disclosed are methods and systems for calculating a contrast reagent (CR) extravasation rate constant and generating a contrast reagent leakage corrected relative cerebral blood volume (rCBV) image map of a brain region from dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI) time-course image data based on pharmacokinetic first principles. In one example approach, a computerized method may include performing a linearization transform of a DSC MRI time-course equation which accounts for an intravascular contribution and an extravasating component, and calculating CR leakage from a slope of a linear portion of the transformed data.
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