BROWN, ADRIAN ST. CLAIR,LAMB, PETER,GALLAGHER, WILLIAM, P.
申请号：
HK12104893.6
公开号：
HK1164305B
申请日:
2012.05.18
申请国别(地区):
HK
年份:
2013
代理人:
摘要：
Disclosed are malate salts of N-(4-{[6,7-bis(methyloxy)-quinolin-4-yl]oxy}phenyl)-N&prime；-(4-fluorophenyl)cyclopropane -1,1-dicarboxamide, including a (L)-malate salt, a (D)-malate salt, a (DL) malate salt, and mixtures thereof； and crystalline and amorphous forms of the malate salts. Also disclosed are pharmaceutical compositions comprising at least one malate salts of N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N&prime；-(4-fluorophenyl)-cyclopropane-1,1-dicarboxamide； and methods of treating cancer comprising administering at least one malate salt of N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N&prime；-(4-ffuorophenyl)cyclopropane-1,1-dicarboxamide.
