ASHWELL, SUSAN,CAMPBELL, ANN-MARIE,CARAVELLA, JUSTIN ANDREW,DIEBOLD, R. BRUCE,ERICSSON, ANNA,GUSTAFSON, GARY,LANCIA, DAVID R., JR.,LIN, JIAN,LU, WEI,WANG, ZHONGGUO
申请号:
CA2961811
公开号:
CA2961811A1
申请日:
2015.09.18
申请国别(地区):
CA
年份:
2016
代理人:
摘要:
The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: (I) where A, B, U, V, Z, W1, W2, W3, and R1-R6 are described herein.