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LIPIDOÏDES AMINOALCOOL ET LEURS UTILISATIONS
专利权人:
Massachusetts Institute Of Technology
发明人:
申请号:
EP17179391.2
公开号:
EP3269395A1
申请日:
2009.11.06
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
Aminoalcohol lipidoids are prepared by reacting an amine with an epoxide-terminated compound are described. Methods of preparing aminoalcohol lipidoids from commercially available starting materials are also provided. Aminoalcohol lipidoids may be prepared from racemic or stereochemically pure epoxides. Aminoalcohol lipidoids or salts forms thereof are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these aminoalcohol lipidoid compounds, they are particularly suited for the delivery of polynucleotides. Complexes, micelles, liposomes or particles containing the inventive lipidoids and polynucleotide have been prepared. The inventive lipidoids may also be used in preparing microparticles for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.
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中国工程科技知识中心
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