Hendrik Jan Bosch;Hendrikus Antonius Cornelis Bakker
发明人:
Hendrikus Antonius Cornelis Bakker,Hendrik Jan Bosch
申请号：
US13458083
公开号：
US08907163B2
申请日:
2012.04.27
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The invention relates to the field of glycoprotein processing in transgenic plants used as cost efficient and contamination safe factories for the production of recombinant biopharmaceutical proteins or pharmaceutical compositions comprising these. The invention provides a plant comprising functional mammalian β1,4-galactosyltransferase and mammalian sialyl transferase for producing complex N-linked glycans that are galactosylated and sialylated, said plant additionally comprising at least a second mammalian protein or functional fragment thereof that is normally not present in plants.
