Pyrimidine derivatives as PIM kinase inhibitors and preparation methods and use in medicinal manufacture thereof

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专利权人:

发明人:

Yu Ge

申请号：

US14746638

公开号：

US09453003B2

申请日:

2015.06.22

申请国别(地区):

US

年份:

2016

代理人:

摘要：

PIM kinase inhibitor compound having a structure as represented by Formula I, and isomers, diastereomers, enantiomers, tautomers, and pharmaceutically acceptable salts thereof. The compounds significantly inhibit the Pim kinase activity and are used to prepare drugs to treat PIM kinase mediated diseases, such as cancers, multi drug resistance, and inflammatory bowel disease. Also provided are methods for preparing and using the compounds represented by Formula I.

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