The invention includes a shunt for at least partial implantation into a patientthat includes an elongated conduit having at least one lumen therethrough, thatincludes a proximal end for receipt of bodily fluids for flow through the shuntand a distal end for discharge of the bodily fluids from the shunt, and a long termsource of at least one occlusion resistant agent, wherein said at least a portionof the at least one occlusion resistant agent can permeate through at least a portionof the elongated conduit. The invention also includes kits and systems.