The Regents of the University of Colorado, A Body Corporate;Department of Veterans Affairs (US);MUSC Foundation For Reaearch Development
发明人:
Baerbel M. Rohrer,Michael Holers,Stephen Tomlinson,Joshua M. Thurman,Carl Atkinson,Liudmila Kulik
申请号：
US14807521
公开号：
US20160083469A1
申请日:
2015.07.23
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention provides targeted delivery methods and constructs for treating inflammatory diseases and/or detecting in vivo tissue injuries in an individual. The targeted delivery approach utilizes an antibody that recognises an epitope found to be present at sites of inflammation. The invention also provides methods of inhibiting complement-driven inflammation in the eye in an individual, comprising administering to the individual an antibody or a fragment thereof or compositions thereof, wherein the antibody or fragment thereof specifically binds to Annexin IV or phospholipid. Also provided are related methods of treating a complement-associated ocular disease or an ocular disease involving oxidative damage. Additionally, the invention provides methods of detecting complement-mediated injury in an eye tissue of an individual, comprising administering to the individual a construct or compositions thereof, wherein the construct comprises (a) an antibody or fragment thereof that specifically binds to Annexin IV or phospholipid； and (b) a detectable moiety.
