INHIBITION DE MÉTASTASES PAR DES COMPOSÉS QUI INHIBENT LA PARTIE PERSISTANTE DES CANAUX SODIQUES DÉPENDANTS DU VOLTAGE

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专利权人:

Celex Oncology Innovations Limited

发明人:

申请号：

EP16020321.2

公开号：

EP3132791B1

申请日:

2010.10.13

申请国别(地区):

EP

年份:

2019

代理人:

摘要：

Substances are disclosed for use in reducing or preventing metastatic behaviour in VGSC expressing cancer by the effect of at least reducing the persistent part of the voltage gated sodium channel current without eliminating the transient part. Inhibition of metastatic cell behaviours such as detachability, lateral motility, transverse migration and invasiveness is demonstrated using the known drugs ranolazine and riluzole.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/