Disclosed herein are various embodiments of a system and a method for pharmaceutical packaging with an audio warning and/or instruction. In accordance with one aspect of the approach, an sound generating pharmaceutical package includes a medical container having an interior space, a cover for preventing unauthorized access to the interior space, a sound module affixed to the medical container, the sound module containing a pre-recorded digital medical notice and a means for playing the digital warning and a trigger mechanism configured to cause the sound module to play the medical notice when the cover is moved to allow access to the interior of the container.