OLAF DR. PETERS,NICO DR. BRUER,MARKUS DR. KOPPITZ,ULRICH DR. BOTHE,JENS DR. NAGEL,GERNOT DR. LANGER
申请号：
ARP140104774
公开号：
AR098843A1
申请日:
2014.12.19
申请国别(地区):
AR
年份:
2016
代理人:
摘要：
This document refers to benzene derivatives in general formula (1),to procedures for its preparation, as well as its use for the preparation of pharmaceutical agents for the treatment of diseases and indications that are related to the EP4 receptor. Claim 1: Compounds of the general formula (1) wherein A represents hydrogen, bromine, cyano, formyl, C₁₋₃ alkyl,Isomerization of 4-6 members, isomerization of 5-6 members, r1-c (= O) (- (ch8322246),R R N-C (3DO) - (CH) -R O-S (3DO) - (CH) -R R N-S (3DO) - (CH) -(Alquil C) -S (3DO) -(Alquil C) -S (3DO) (3DNH) - o (cicloalquil C) -S (3DO) (3DNH) -In isopropene, isopropene is best selected from a group consisting of PYRAZOLIN, pyridan methanol, triazoline, tetrazolidine, oxazolilo, isoxazolilo and oxadiazolilo, where tar may be an optional mono nitrogen or polybrominated diphenyl ether, replaced by halogen or hydrogen Xi, whether or not it is different, There, the isomerized radicals may be monomorphic or polygonal, the same or different, using pitch c833133,trifluoromethyl or hydroxy, and wherein the heteroaryl radicals may optionally be mono- or polysubstituted, the same or different, with C₁₋₃ alkyl,3. Trifluoroidyl or hydroundecyl； B is selected from the formula group structure (2),It means the connection point in the molecule； R1 74919,RR 749595 stands for hydrogen, cyanogen and c832131 asphalt independently；C₂₋₅ alkenyl,C₂₋₅ alkynyl,(Cicloalquil C) - (CH) -(4-6 members of isoacrylonitrile) - (ch8322) - 8345； -,(Alcoxi C) - (alquilo C) -(Cicloalcoxi C) - (alquilo C) -H83222； - N - (rent c832131)(Alquil C) NH- (alquilo C) - o (alquil C) N- (alquilo C) -wherein the heterocyclyl is preferably selected from the group consisting of oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, 1,4-dioxanyl, morpholinyl, azetidinyl, pyrrolidinyl, piperazinyl and piperidinyl, and wherein the alkyl radicals, cycloalkyl radicals and heterocyclyl radicals may optionally be mono - or polysubstituted, the same or different, with halogen, C₁₋₅ al
