SHIH CHARLES C-Y,KITAMURA TOSHIO,SHI QIAN,KAWASHIMA TOSHIYUKI,WANG HUI-KANG
申请号：
NZ60765311
公开号：
NZ607653A
申请日:
2011.08.16
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
Provided are 1,5-diphenylpenta-1,4-dien-3-one derivative compounds of Formula (I), (II), or (III) where the variables are as described herein. Particularly preferred are compounds of formula (III) wherein at least one of R1, R2, R3 , R4 ,R5 ,R1&rsquo, R2&rsquo, R3&rsquo, R4&rsquo and R5&rsquo is RdS(O)2-O-, (Rd)2P(O)-O-, or (RdO)2P(O)-O-. The compounds deactivate Signal Transducer and Activator of Transcription (STAT) proteins. These compounds may be used in the treatment of cancer, inflammatory diseases, or autoimmune diseases.
