Oral care compositions comprising one or more active agents and hydroxypropyl cellulose, and that are liquid at or below room temperature and which form a two-phase cloudy system at body temperature. In certain embodiments the active agent is a mineralizing agent, an anti-caries agent, an anti-inflammatory agent, an antibacterial agent, an antifungal agent, an anti-malodour agent or a mixture thereof.本發明揭示口腔護理組成物,其包含一或多種活性劑及羥丙基纖維素,且其在室溫下或低於室溫時為液體且其在體溫下形成兩相混濁系統。在某些實施例中,該活性劑係礦化劑、抗齲齒劑、抗炎劑、抗細菌劑、抗真菌劑、抗惡臭劑或其混合物。