The present invention relates to a transdermal therapeutic system for the transdermal administration of guanfacine comprising a guanfacine-containing layer structure, said guanfacine-containing layer structure comprising:A) a backing layer; andB) a guanfacine-containing layer;wherein the transdermal therapeutic system comprises at least one silicone acrylic hybrid polymer.本發明關於一種用於經皮投予胍法辛之經皮治療系統,其包括含胍法辛的層結構,該含胍法辛的層結構包含:A) 背襯層;及B) 含胍法辛的層;其中該經皮治療系統包含至少一種聚矽氧丙烯酸系混成聚合物。