Provided herein is a female hormone-containing patch whereinan active ingredient is highly soluble in a pressure-sensitiveadhesive layer and the active ingredient is not adsorbed to abacking, and the patch per se can follow the irregularities on theskin surface or body movements. The patch is an external patchcontaining, as a female hormone, a follicular hormone estradioland/or its derivative or a progestational hormone norethisteroneand/or its derivative. The external patch comprises an acrylicpressure-sensitive adhesive containing 0.01 to 1% by weight of anisocyanate-based crosslinking agent as an essential ingredient.
