STRITTMATTER, WOLFGANG DR,GUESSOW, DETLEF,HOFMANN, UWE,HEMBERGER, JUERGEN,FOTEV, ZISI,SCHEUBLE, BERNHARD
申请号：
HU0200353
公开号：
HU228068B1
申请日:
2000.03.10
申请国别(地区):
HU
年份:
2012
代理人:
摘要：
A naturally occurring protein isolated from the saliva of the medicinal leech Hirudo medicinalis is described which strongly binds to collagen thus acting as an inhibitor of natural platelet adhesion to collagen. The protein has a molecular weight of about 12,000, an acidic isoelectric point and contains six cysteins. The protein was sequenced and the gene was cloned from a H. medicinalis cDNA-library. Procedures for producing such polypeptide by recombinant techniques are disclosed. The recombinant and the natural occurring proteins are potent inhibitors of collagen-dependent platelet adhesion and therefore useful for the therapeutic treatment of various conditions related to heart disease and diseases of the circulation system. Furthermore, the protein is useful for coating natural or artificial collagen surfaces in order to render them nonadhesive for cells and prevent the activation of cells.
