BALINT, JOSEPH,JONES, FRANK R.,RICE, ADRIAN,GABITZSCH, ELIZABETH,LATCHMAN, YVETTE
申请号:
CA3010874
公开号:
CA3010874A1
申请日:
2017.01.13
申请国别(地区):
CA
年份:
2017
代理人:
摘要:
Methods for constructing and producing a recombinant adenovirus based vector vaccine containing multiple influenza antigen genes for use in generating broad based immune responses against influenza A and B viruses and that allows for multiple vaccinations in individuals with preexisting immunity to adenovirus are described. Specifically, the recombinant adenovirus based vector is a replication defective adenovirus vector comprising a deletion in an early 2b (E2b) gene.