MODIFICATION DIRIGÉE SUR SITE DE FVIII

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专利权人:

Bayer HealthCare LLC

发明人:

申请号：

EP17166910.4

公开号：

EP3243833A1

申请日:

2005.11.14

申请国别(地区):

EP

年份:

2017

代理人:

摘要：

This invention relates to Factor Vill muteins that are covalently bound, at a predefined site that is not an N-terminal amine, to one or more biocompatible polymers such as polyethylene glycol. The mutein conjugates retain FVIII procoagulant activity and have improved pharmacokinetic properties.

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