Compositions and methods for effecting the levels of high density lipoprotein (HDL) cholesterol and apolipoprotein AI very low density lipoprotein (VLDL) cholesterol and low density lipoprotein (LDL) cholesterol
JAYE MICHAEL,LYNCH KEVIN J,AMIN DILIP V,DOAN KIM-ANH THI,MARCHADIER DAWN,MAUGEAIS CYRILLE,RADER DANIEL J,KRAWIEC JOHN A,SOUTH VICTORIA J
申请号：
NO20100214
公开号：
NO331784B1
申请日:
2010.02.11
申请国别(地区):
NO
年份:
2012
代理人:
摘要：
The present invention relates to compositions for use in raising or lowering the level of LIPG polypeptide in a patient. Embodiments of the composition include compositions comprising: an anti-sense nucleic acid； a neutralizing antibody； an intracellular binding protein； an inhibitor which inhibits the enzymatic activity of LIPG polypeptide； an inhibitor which inhibits the expression of LIPG gene； a ribozyme； an LIPG polypeptide； an enhancer which increases the enzymatic activity of LIPG polypeptide； or an enhancer which increases the expression of LIPG gene. The invention relates also to methods for using the above compositions.In addition, the invention relates to a method for diagnosing a predisposition to lower cholesterol, a method for determining whether a test compound can inhibit the enzymatic reaction between LIPG polypeptide and HDL cholesterol, and methods for determining whether a test compound can enhance the enzymatic reaction between LIPG polypeptide and LDL or VLDL cholesterol.Preparater og fremgangsmåter for å forhøye nivået av HDL-kolesterol og apolipoprotein AI i en pasient og for reduksjon av nivået av VLDL-kolelsterol og LDL-kolesterol i en pasient, innbefattet preparater og fremgangsmåter som påvirker ekspresjonen av et gen, LIPG, som koder for et lipaseenzym som er et medlem av triacylglyserollipasefamilien,eller som påvirker enzymets enzymatiske aktivitet.
