Various systems, apparatus and methods are described herein for generating cardiac, cardiopulmonary, and/or hemodynamics phenotypes of patients for use in various applications. In various embodiments, a ventilation support apparatus connected to a patient may be operated to perform a therapeutic maneuver selected to cause one or more targeted receptors of the patient to initiate an autoregulation response in the patient. In various embodiments, a measurement may be taken of one or more changes in a vital sign of the patient such as blood pressure that is caused by initiation of the autoregulation response in the patient. In various embodiments, a cardiac, cardiopulmonary, or hemodynamic phenotype of the patient may be generated based on the measured one or more changes.
