PRESIDENT AND FELLOWS OF HARVARD COLLEGE;THE CHANCELLOR, MASTERS, AND SCHOLARS OF THE UNIVERSITY OF OXFORD
发明人:
FLANAGAN, JOHN G.,SHEN, YINGJIE,JONES, EDITH YVONNE,ARICESCU, ALEXANDRU RADU,COLES, CHARLOTTE HANNAH
申请号：
CA2827383
公开号：
CA2827383A1
申请日:
2012.02.17
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
Disclosed herein are methods of inducing neuronal outgrowth of a neuron. The methods comprise contacting the neuron with an agent that binds receptor protein tyrosine phosphatase d (RPTPd), to thereby induce neuronal outgrowth of the neuron. The agent may induces clustering of RPTPd and/or inhibit binding of chondroitin sulfate proteoglycan (CSPG) to RPTPd. Examples of suitable agents are heparan sulfate proteoglycan, heparan sulfate, heparan sulfate oligosaccharides, or heparin oligosaccharides. Additional agents are also disclosed. The neuron can be a CNS neuron or peripheral neuron. Also disclosed herein are methods of treating neuronal injury in a subject comprising, administering to the subject an agent that binds RPTPd. Administration may be to a site of neuronal injury, to thereby induce neuronal outgrowth at the site of neuronal injury.
