The present invention provides novel alkyl phospholipid derivatives with reduced cytotoxicity that are useful for treating various diseases and/or pathophysiological conditions in mammals, preferably humans, that are caused by microorganisms, in particular bacteria, fungi, protozoa and/or viruses. Such alkyl phospholipids can be employed as single drugs or in the course of combination therapies and can also be used for the treatment of tumors.本發明提供細胞毒性減低之新穎烷基磷脂衍生物,其可用於治療由微生物,尤其細菌、真菌、原蟲和/或病毒所引起的各種哺乳動物(尤其人)的疾病和/或病理生理狀況。該烷基磷脂類可以用作單一藥劑使用或於組合療法的療程中使用,也可用於治療腫瘤。