BEERS, COURTNEY,比尔斯 科特尼,比爾斯 科特尼,NEILL, JASON C.,欧尼尔 杰森 C O’,歐尼爾 傑森 C O’,FOLTZ, IAN,福尔兹 伊恩,福爾茲 伊恩,KETCHEM, RANDAL R.,凯臣 蓝道 R,凱臣 藍道 R,PIASECKI, JULIA C.,皮亚塞茨基 茱莉亚 C,皮亞塞茨基 茱莉亞 C
申请号：
TW103129286
公开号：
TW201605896A
申请日:
2014.08.26
申请国别(地区):
TW
年份:
2016
代理人:
摘要：
Antigen binding proteins that activate GITR are provided. Nucleic acids encoding the antigen binding proteins and vectors and cells containing such nucleic acids are also provided. The antigen binding proteins have value in therapeutic methods in which it is useful to stimulate GITR signaling, thereby inducing or enhancing an immune response in a subject. Accordingly, the antigen binding proteins have utility in a variety of immunotherapy treatments, including treatment of various cancers and infections.提供一種活化GITR的抗原結合蛋白。亦提供編碼抗原結合蛋白的核酸和含有這些核酸的載體以及細胞。抗原結合蛋白在治療方法中具有價值,在該方法中,其是有用於刺激GITR訊息,因此誘導或增進主體內的免疫反應。因此,該抗原結合蛋白具有在各種免疫療法治療內的效用,包含各種癌症和感染的治療。
