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Broken inactive vaccine and its obtaining method
专利权人:
FEDERALNOE GOSUDARSTVENNOE UNITARNOE PREDPRIYATIE "SANKT-PETERBURGSKY NAUCHNO-ISSLEDOVATELSKY INSTITUT VAKTSIN I SYVOROTOK I PREDPRIYATIE PO PROIZVODSTVU BAKTERYNYKH PREPARATOV" FEDERALNOGO MEDIKO-BIO
发明人:
VIKTOR PAVLOVICH TRUKHIN,STANISLAV VIKTOROVICH PETROVSKY,SERGEY ALEKSANDRVICH ARAKELOV,DMITRIY GENNADIEVICH BYKOV,ANATOLIY EDUARDOVICH EVTUSHENKO,STANISLAV VALENTINOVICH UYBA,VITALIY NIKOLAEVICH GRANO
申请号:
NI201700158
公开号:
NI201700158A
申请日:
2017.12.14
申请国别(地区):
NI
年份:
2018
代理人:
摘要:
The invention involves immunity, medicine, pharmacology, and the production of inactive anti-virus vaccines, which can be used to vaccinate the Russian people against influenza. The mediums used to treat influenza include infection of chicken embryo infected with influenza virus, incubation of infected embryo, cooling of incubated embryo, collection of infected formic acid anhydride solution, and treatment of infected formic acid anhydride solution Its decomposition and inactivity, microfilm infection by formic anhydride in two series of cartridge cases,2. Filter and purify the infected acrylic acid solution on the sugar density gradient. The purification and fragmentation of the inactive virus concentrate used β - octaloglus detergent, virgin removal without complete destruction, and the fragmentation of the membrane protein ribonucleoprotein complex using ultracentrifugation. The final purification of the isolated antigens will be carried out in a chromatographic environment, and then a stabilizer will be added to the obtained antigens. The difference is that the activity of the virus stops,In the phase of using the b-acrylic disinfectant to deal with the infected acrylic acid solution, we decompose the virus in the process of dealing with the infected acrylic acid solution, and decompose it with sodium chloride in the final concentration. The final antigen purification was carried out in the workbeads 40 / 100 / sec chromosome of Bioworks, Sweden,Use Triton X-100 detergent to stabilize the concentration at 100-300? G / ml. also proposed a drug for the treatment of influenza, which is produced by the above methods.La invención se refiere a Inmunología, medicina, farmacología y se relaciona con la producción de vacunas antigripales inactivadas, las cuales pueden ser utilizadas para la vacunación de la población de Rusia contra la gripe. Método para la obtención de un medio destinado a la curación de la gripe que incluye la infección de embriones de pollo con el vir
来源网站:
中国工程科技知识中心
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