Georg Tschank;Gerhard Seipke;Mark Sommerfeld;Ulrich Werner;Paul Habermann;Norbert Tennagels;Roland Kurrle;Gunter Muller
发明人:
Paul Habermann,Gerhard Seipke,Roland Kurrle,Gunter Muller,Mark Sommerfeld,Norbert Tennagels,Georg Tschank,Ulrich Werner
申请号：
US12820722
公开号：
US09644017B2
申请日:
2010.06.22
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The invention relates to novel insulin analogs having a basal time-action profile, which are characterized by the following features: a) the B chain end consists of an amidated basic amino acid residue such as lysine or arginine amide； b) the N-terminal amino acid residue of the insulin A chain is a lysine or arginine radical； c) the amino acid position A8 is occupied by a histidine radical； d) the amino acid position A21 is occupied by a glycine radical； and e) one or more substitutions and/or additions of negatively charged amino acid residues are carried out in the positions A5, A15, A18, B-1, B0, B1, B2, B3 and B4.
