METHOD FOR INCREASING IMMUNOREACTIVITY OF LYMPHOCYTES TO ANTIGEN

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专利权人:

MEDIZINISCHE UNIVERSITAT INNSBRUCK

发明人:

BAIER, GOTTFRIED,LOIBNER, HANS,SCHUSTER, MANFRED,LAMETSCHWANDTNER, GUNTHER,WOLF, DOMINIK

申请号：

NZ58564608

公开号：

NZ585646A

申请日:

2008.12.10

申请国别(地区):

NZ

年份:

2012

代理人:

摘要：

A method to increase the immunoreactivity of cells of the immune system by reducing or inhibiting the Cbl-b function of the cells by using a short DNA or RNA sequence complementary to a part of the Cbl-b mRNA sequence. The method can be used to transiently increase the immunoreactivity of CD8+ or CD4+ T cells to a desired antigen. The inhibitory DNA or RNA sequences can be used to treat immunoinsufficiency in diseases such as AIDS, multiple myeloma, chronic lymphatic leukaemia, drug induced immunosuppression or cancer.

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