USE OF DRONEDARONE ALONE OR IN COMBINATION FOR PREPARING A MEDICAMENT FOR THE TREATMENT OF PATIENTS WITH ARRHYTHMIA AND HAVING AN INCREASE OF CREATININE LEVEL
Disclosed is the use of dronedarone or one of its pharmaceutically acceptable salts for preparing a medicament for the treatment of arrhythmia, wherein the arrhythmia is in a patient having an increase of creatinine level due to dronedarone administration, said creatinine level increasing following dronedarone treatment initiation, said creatinine level increase reaching a plateau and being used as a new baseline, said creatinine level increase being reversible after dronedarone discontinuation, wherein said medicament is in a form for administration according to a treatment regime which involves the following steps: initiating dronedarone treatment； measuring serum creatinine level increases following dronedarone treatment initiation, which provides a reference level, said serum creatinine level reaching a plateau； discontinuing temporarily dronedarone； measuring that the increase is reversible after dronedarone discontinuation； and continuing dronedarone treatment.
