A computer-implemented method, system, and computer-readable medium, for determining a pathologic condition from a medical image of a portion of a subject. The method includes acquiring a plurality of lesion locations in the medical image； applying a clustering algorithm to the plurality of lesion locations to identify at least one lesion cluster and corresponding lesion cluster data； categorizing each lesion cluster into one of a set of predetermined categories based on the identified lesion cluster data； applying at least one function to the lesion cluster data with regard to each category of the set of predetermined categories, wherein the at least one function provides a fixed number of data outputs； and determining a pathologic condition by processing the fixed number of data outputs of each category of the set based on a classification algorithm trained on image data defining medical images of the portion of a plurality of subjects.
