LEACH, MICHAEL,HARBIGE, LAURENCE,RIDDALL, DIETER,FRANZMANN, KARL
申请号：
CA2712070
公开号：
CA2712070C
申请日:
2009.01.16
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
Compounds of general structure in which X and Y are each N or C with at leastone of X and Y being N Z is asingle bond or an optionally substituted linking group R1 is hydrogen or asubstituent group R2 is amino or a substituent group N*is amino when RI is hydrogen or =NH when R1 is a substituent group or N* is agroup NR a R b where R a and R b are independentlyH or an alkyl group or N* is an optionally substituted piperazinyl ring andA is an optionally substituted heterocyclic or carbocyclicring system which may be linked to the triazo/diazo ring through R2 to form afused multicyclic ring are indicated as suitable fortreatment of disorders in mammals that are susceptible to sodium channelblockers and antifolates, and particularly disorders suchepilepsy, multiple sclerosis, glaucoma and uevitis, cerebral traumas andcerebral ischaemias, stroke, head injury, spinal cord injury,surgical trauma, neurodegenerative disorders, motorneurone disease,Alzheimers disease, Parkinsons disease, chronic inflammatorypain, neuropathic pain, migraine, bipolar disorder, mood, anxiety andcognitive disorders, schizophrenia and trigeminal autonomiccephalalgias for treatment of mammalian cancers and for treatment ofmalaria.
