HIV integrase inhibitors from pyridoxine

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专利权人:

Brent Stranix

发明人:

Brent Stranix,Francis Beaulieu,Jean-Emmanuel Bouchard,Guy Milot,Wang Zhigang,Réjean Ruel

申请号：

US12995890

公开号：

US08742123B2

申请日:

2009.06.04

申请国别(地区):

US

年份:

2014

代理人:

摘要：

The present invention relates to pyridoxine (vitamin B6) derived compounds of formula (I), pharmaceutically acceptable salts, or solvates thereof, wherein R1, R2, R4, A, L B1 and B2 are as defined in the specification, and pharmaceutical compositions comprising the compounds. Compounds of formula (I) inhibit Human Immunodeficiency Virus (HIV)-integrase enzyme and are useful for preventing and treating HIV infection and AIDS.

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