The present invention provides a compound of Formula (I) or a pharmaceutically acceptable salt thereof wherein R1, R2, R3, A1, A2, A3, A4, L, B1, B2, B3 and B4 are as defined herein. The compounds of Formula I have been found to act as glucagon antagonists or inverse agonists. Consequently, the compounds of Formula I and the pharmaceutical compositions thereof are useful for the treatment of diseases, disorders, or conditions mediated by glucagon.本發明提供式(I)化合物：或其醫藥學上可接受之鹽，其中R1、R2、R3、A1、A2、A3、A4、L、B1、B2、B3及B4如本文所定義。已發現式I化合物可充當升糖素拮抗劑或反向促效劑。因此，式I化合物及其醫藥組合物適用於治療由升糖素介導之疾病、病症或病狀。
