#$%^&*AU2017261475A120171130.pdf#####I: sxdInterwoven NRPortbl DCC SXD 5961199 _Idocx--13 /t2017 ABSTRACT The present invention relates to compounds of formula (I) and their pharmaceutical compositions. In addition, the present invention relates to therapeutic methods for the 5 treatment and/or prevention of Ap-related pathologies such as Down's syndrome, Pamyloid angiopathy such as but not limited to cerebral amyloid angiopathy or hereditary cerebral hemorhage, disorders associated with cognitive impairment such as but not limited to MCI ("mild cognitive impairment"), Alzheimer's disease, memory loss, attention deficit symptoms associated with Alzheimer's disease, neurodegeneration 10 associated with diseases such as Alzheimer's disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease.WO 2012/087237 PCT/SE2O1 1/051555 1/8 FIG. IA "'ot 4k ~ ~ tA 't'~w V"V
