ZHOU, HAN-JIE,SUN, CONGCONG, M.,SHENK, KEVIN, D.,LAIDIG, GUY, J.
申请号：
PH12013501656
公开号：
PH12013501656A1
申请日:
2013.08.08
申请国别(地区):
PH
年份:
2016
代理人:
摘要：
Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases associated with the proteasome. The peptide-based compounds include an epoxide or aziridine, and functionalization at the N-terminus. Among other therapeutic utilities, the peptide-based compounds are expected to display anti- inflammatory properties and inhibition of cell proliferation. Oral administration of these peptide-based proteasome inhibitors is possible due to their bioavailability profiles.
