FOGET ROKA Montserrat (DE),ФОГЕТ РОКА Монтсеррат (DE),FOGET ROKA MONTSERRAT,ФОГЕТ РОКА Монтсеррат
申请号：
RU2009128179/15
公开号：
RU0002491917C2
申请日:
2007.12.21
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
FIELD: medicine.SUBSTANCE: group of inventions refers to a nanoemulsion for active agent delivery, a method for preparing it, compositions containing it, and to using a nanoemulsion for preparing pharmaceutical compositions for local application and cosmetic compositions for skin application. The declared nanoemulstion contains a water ingredient and a carrier which contains a lipophilic ingredient in the amount of 0.1-15 wt %, a surfactant and isopropyl and/or 1-propyl alcohol. The average emulsified particle diameter makes less than 100 nm. The method for preparing the nanoemulsion involves mixing the water ingredient and carrier containing the lipophilic ingredient, surfactant and isopropyl and/or 1-propyl alcohol, for preparing the nanoemulsion at temperature 50-60°C. The invention also refers to the composition for photodynamic therapy containing the above nanoemulsion and the active agent representing 5-aminolevulinic acid, a derivative, a precursor and/or a metabolite thereof. The above composition is applied to prepare the drug substance for photodynamic therapy and to treat senile keratosis. What is also declared is a diagnostic composition for detecting the dividing cells which contains the nanoemulsion and 5-aminolevulinic acid. The invention also refers to a kit for photodynamic therapy which comprises the composition for photodynamic therapy and one ingredient specified in a photoresist coating, an agent for attaching the above coating or an agent for applying the composition.EFFECT: invention provides better stability and intensified cell and tissue penetration of the nanoemulsion.25 cl, 6 dwg, 9 tbl, 5 exГруппа изобретений относится к наноэмульсии для доставки активного агента, способу ее получения, композициям, ее содержащим, и к применению наноэмульсии для производства фармацевтических композиций для местного нанесения и косметических композиций для нанесения на кожу. Заявленная наноэмульсия содержит водный компонент и носитель, который включает л
