A use of an euryale seed extract in the manufacture of a composition is provided, wherein the composition is used for inhibiting expression ofICAM-1gene. Accordingly, the composition is effective in treating, preventing or regulating diseases or physiological functions related withICAM-1gene.一種使用芡實萃取物於製造一組合物之用途,其中該組合物係用於抑制ICAM-1基因表現,從而達到治療、預防或調節與ICAM-1基因相關之疾病或生理機能的效果。